Pioneering Generational Health @ DAVOS 2024
Sanskriti Thakur is Chairwoman of Tower Capital Group and the pioneer of Generational Health. Her career has been focused on Health and Economic Transformation, exemplified by pioneering the category of Generational Health, leading pandemic disaster response, serving on World Economic Forum councils, and heading life science research for a $60B consultancy.
Additionally, one of the first females in corporate venture capital for Digital Health, she has led a $2.3B growth-stage company revolutionizing medicine. Over her career, Sans has published over 18 research articles in the areas of science, health, business and technology intersections.
Vani Rao is President of Tower Collective and has two decades of capital markets experience across derivatives, structured products, and venture capital, Vani is seasoned investor and an activist for gender parity, focused on promoting capital access to entrepreneurs to build healthier economies. Vani is currently the President of Tower Capital, an economic development organization focused on defining and growing the market for generational health encompassing women, environment, and community. Vani is an active investor as Venture Partner with Mastersfund, a gender lensed early stage VC fund. Vani is a CFA Charterholder, has a Master’s degree in Financial Engineering from Kent State University, and a Bachelor’s Degree in Mathematics from New York University.
Pioneering Generational Health
It is vital to understand the intersections of Generational health with critical outcomes sought by industry, markets and countries. There is no longer a separation between the impacts on our planet and those of human physiology.
Generational health represents a responsible and pragmatic view of the health effects collectively passed onto the next many generations.
TOWER is the pioneer in exploring the market and investable portfolios of generational health entities. It is our mission to coalesce the leading stakeholders towards focused funding into the category of Generational Health.
TOWER CAPITAL GROUP LLC, is an economic development entity responsible for defining, developing and funding the category of Generational Health.
Generational Health are those effects passed on genetically, epigenetically and environmentally, shaping humanity's evolutionary curve.
These effects are scientifically and systemically measurable. They represent a multi-trillion dollar opportunity for both the public and private sector growth.
Operating across industries, regions and partners, TOWER and its affiliates deploy expertise and capital to uncover economic value, investment and innovation within Generational Health and bring it to stakeholders across the globe.
Introduction to Generational Health
In 2018, the National Academies of Science Engineering and Medicine published a consensus study report in which they defined a framework for Generational Health, simplified and adapted as: those health effects passed on genetically, epigenetically and/or environmentally to future generations.1 The publishing committees were acting upon the need to understand generational, multi & trans generational impact on veterans and children of war and conflict. Multiple factors with potential to shape future generations were considered. The evolution in precision science and within genetics and epigenetics continue to enlighten the body of research. These factors are foundational to Generational Health.
Today, as large parts of the globe undergo conflicts, this study serves as a baseline for understanding of the historical and the probable. TOWER leverages this robust research and, with it, shapes a market strategy. It broadens the view beyond war and into daily life where these challenges to human physiology penetrate. It deepens the focus on prevailing environmental toxins, the rise of mental health crises, and inequity within communities, women and children.
With this focus, TOWER identifies the opportunities and entities that strictly bring solutions that directly impact Generational Health effects passed onto the future. A primary evaluation resides on the market and then a subset of innovators’ potential for growth. It requires that each entity demonstrates strong likelihood to create returns. Without this, Generational Health will not sustain amongst the fads, and cynics.
Learn more in our White Paper, released on January 18th 2024.
(1)National Academies of Sciences, Engineering, and Medicine. 2018. Gulf War and health, volume 11: Generational health effects of serving in the Gulf War. Washington, DC: The National Academies Press. doi: https://doi.org/10.17226/25162.
Literature analyses across approximately eighty thousand scientific papers, and as described thoroughly by that National Academies 1, and adapted below, categorizes the scientific areas of focus as follows:
Reproductive effects: any effect on the ability to reproduce. Including, effects on male reproduction, such as changes in sperm parameters and reproductive hormones, infertility, time to pregnancy; Effects on female reproduction, including effects on menstrual cycle, endometriosis, in-fertility, time to pregnancy, changes in reproductive hormones; Adverse pregnancy outcomes, including the spectrum of pre-post Maternal health, such as gestational diabetes, gestational hypertension, and inflammation during pregnancy; and Birth outcomes, such as preterm birth, birth weight or size, spontaneous abortion, and still-birth.
Developmental effects: any adverse health effects in children or offspring of any age, including reproductive effects. Neurodevelopmental deficits, including measures of cognition (IQ, attention, motor skills, etc.), autism spectrum disorders, attention deficit disorders; Respiratory effects, including respiratory symptoms (e.g., wheezing), lung function, asthma, respiratory infections; Childhood cancers; Birth defects; Immune outcomes: eczema, dermatomyositis; Obesity and metabolism; and Growth.
Epigenetic and genetic effects, including Markers of DNA oxidative stress; DNA methylation in maternal blood, umbilical cord blood, placenta, or peripheral blood lymphocytes, sperm; mRNA expression; Histone modifications; and Mitochondrial DNA content in umbilical cord blood.
Across all stages, exposure in the environment is considered. When science extrapolates to markets, we propose that in simple terms, three main areas intersect: Environment, Community (inclusive of Mental and Pediatric health) and Women. In totality, it is notable that they sum up to overall impacts to human longevity, quality of life and reproductive capacity
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